Back to Search
Start Over
1,25-Dihydroxyvitamin D3 and the regulation of macrophage function
- Source :
- Calcified Tissue International; December 1981, Vol. 33 Issue: 1 p673-676, 4p
- Publication Year :
- 1981
-
Abstract
- Summary: Vitamin D<subscript>3</subscript> deficient (D<superscript>−</superscript>) mice show a depressed inflammatory response and both inflammatory peritoneal macrophages and bone marrow polymorphonuclear leukocytes of D<superscript>−</superscript> mice exhibit a decreased spontaneous migration under agarose. The impaired phagocytic response of peritoneal macrophages from D<superscript>−</superscript> mice can be corrected by incubation with 1,25-dihydroxyvitamin D<subscript>3</subscript> and is not affected by interaction with other vitamin D<subscript>3</subscript> metabolites. Transfer of mice from the D<superscript>−</superscript> to the D<superscript>+</superscript> state results in correction of both the inflammatory and the phagocytic response. Intactness of phagocyte function is thus directly dependent on vitamin D<subscript>3</subscript> metabolism.
Details
- Language :
- English
- ISSN :
- 0171967X and 14320827
- Volume :
- 33
- Issue :
- 1
- Database :
- Supplemental Index
- Journal :
- Calcified Tissue International
- Publication Type :
- Periodical
- Accession number :
- ejs15547327
- Full Text :
- https://doi.org/10.1007/BF02409507