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Disposition of [1,2-14C] vinyl chloride in the rat
- Source :
- Archives of Toxicology; September 1976, Vol. 35 Issue: 3 p153-162, 10p
- Publication Year :
- 1976
-
Abstract
- Rats were exposed to [1,2-<superscript>14</superscript>C] vinyl chloride in a closed system at initial concentrations below 100 ppm. When the system was occupied by 3 rats, a half-life of vinyl chloride in the system's atmosphere of 1.13 ± 0.12 h was observed. The volume of the system was 10.3 l. Calculation of the clearance of vinyl chloride from the system revealed that about 40% of inspired vinyl chloride is absorbed by lung. Therefore, changes in respiration did not influence uptake of vinyl chloride.
Details
- Language :
- English
- ISSN :
- 03405761 and 14320738
- Volume :
- 35
- Issue :
- 3
- Database :
- Supplemental Index
- Journal :
- Archives of Toxicology
- Publication Type :
- Periodical
- Accession number :
- ejs15543543
- Full Text :
- https://doi.org/10.1007/BF00293562