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Effects of linoleic and gamma-linolenic acids (efamol evening primrose oil) on fatty acid-binding proteins of rat liver
- Source :
- Molecular and Cellular Biochemistry; October 1990, Vol. 98 Issue: 1-2 p177-182, 6p
- Publication Year :
- 1990
-
Abstract
- We have studied the effects of Efamol evening primrose oil (EPO) on fatty acid-binding proteins (L-FABP) of rat liver. EPO contains 72% cis-linoleic acid and 9% cis-gamma linolenic acid. EPO has been clinically used for treatment of a number of diseases in humans and animals. EPO is also known to lower cholesterol level in humans and animals. Feeding of an EPO supplemented diet to rats (n = 9) for 2 months decreases the oleate binding capacity of purified L-FABP of rat liver whereas the palmitate binding activity was increased by 38%. However, EPO feeding did not alter the L-FABP concentrations significantly as measured by using the fluorescence fatty acid probe, dansylamino undecanoic acid. Endogenous fatty acid analysis of L-FABPs revealed significant qualititative and quantitative changes in fatty acid pattern after EPO feeding. EPO feeding decreased the endogenous palmitate level by 53% and oleate level by 64% in L-FABPs and also EPO feeding decreased the total endogenous fatty acid content from 62 nanomole per mg of protein to 42 nanomole per mg of L-FABP (n = 3).
Details
- Language :
- English
- ISSN :
- 03008177 and 15734919
- Volume :
- 98
- Issue :
- 1-2
- Database :
- Supplemental Index
- Journal :
- Molecular and Cellular Biochemistry
- Publication Type :
- Periodical
- Accession number :
- ejs15495825
- Full Text :
- https://doi.org/10.1007/BF00231382