Giant cerebriform naevus of the scalp

Giant cerebriform naevi (GCN) are rare scalp lesions which require surgery because of their growth potential and possible malignant behaviour. Three cases of GCN underwent excision and primary repair of the scalp. In one case secondary repair by skin expansion was performed. The histological and immunohistochemical studies showed both melanocytic and neuroid differentiation of the growing cells and characterized the lesions as GCNs. S-100 protein, neurono specific enolase and somatostatin-like cell immunostains were in agreement with the neuroectodermal histogenesis of GCNs suggesting their hamartomatous nature.