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Evaluation of P-glycoprotein expression in soft tissue sarcomas of the extremities

Authors :
Serra, Massimo
Scotlandi, Katia
Manara, Maria Cristina
Maurici, Daniela
Benini, Stefania
Sarti, Manuela
Nini, Giuseppe
Barbanti-Brodano, Giovanni
Baldini, Nicola
Source :
Cytotechnology; October 1996, Vol. 19 Issue: 3 p253-256, 4p
Publication Year :
1996

Abstract

Soft tissue sarcomas comprise a heterogeneous group of mesenchymal tumors accounting for less than one-percent of adult neoplasms. In the last few years, the use of adjuvant chemotorapy has been proposed for the treatment of these lesions in order to obain a better systemic control, but its usefulness is still controversial. In this study, we evaluated whether P-glycoprotein, a membrane protein strictly associated with multidrug resistance, is overexpressed in soft tissue sarcomas. By using human multidrug resistant sarcoma cell lines as controls, we analyzed P-glycoprotein expression in 34 primary and in 23 relapsed soft tissue sarcomas of the extremities. Overexpression of P-glycoprotein was found in 6 out of 34 primaries (18%) and in 8 out of 23 relapses (35%). In particular, in malignant fibrous histiocytoma, the most frequent soft tissue sarcoma of adults, P-glycoprotein overexpression was found in 23% of primary untreated cases, in agreement with the reported relapse rate of this tumor after surgery and chemotherapy. These data suggest that, in soft tissue sarcomas, overexpression of P-glycoprotein may be of prognostic value and that the assessment of P-glycoprotein expression may be useful for the design of chemotherapy protocols.

Details

Language :
English
ISSN :
09209069 and 15730778
Volume :
19
Issue :
3
Database :
Supplemental Index
Journal :
Cytotechnology
Publication Type :
Periodical
Accession number :
ejs14985516
Full Text :
https://doi.org/10.1007/BF00744221