5-Hydroxy-6-Quinaldic Acid as a Novel Molecular Scaffold for HIV-1 Integrase Inhibitors

Authors :: Polanski, J.
Niedbala, H.
Musiol, R.
Podeszwa, B.
Tabak, D.
Palka, A.
Mencel, A.
Finster, J.
Mouscadet, J.- F.
Bret, M. L.
Source :: Letters in Drug Design & Discovery; April 2006, Vol. 3 Issue: 3 p175-178, 4p
Publication Year :: 2006
Abstract: 8-Hydroxy-7-quinaldic acid can be considered as a basic scaffold for all reported styrylquinoline HIV-1 integrase inhibitors. However, when tested in vitro, this compound appeared to be inactive against the enzyme. We have designed and synthesized an improved molecular fragment, i.e. 5-hydroxy-8-nitro-6-quinaldic acid, which appeared to inhibit HIV-1 integrase in vitro.

Tools