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Syntheses of R,Snaproxen and its 6Odesmethylated metabolite labelled with 2H
- Source :
- Journal of Labelled Compounds and Radiopharmaceuticals; April 2008, Vol. 51 Issue: 5 p239-241, 3p
- Publication Year :
- 2008
-
Abstract
- Naproxen, a wellknown nonsteroidal antiinflammatory drug, and its 6Odesmethylated metabolite have been labelled with 2H. R,SNaproxen 7 labelled with 2H was obtained in five steps using the commercially available 2H3iodomethane 5 as the stable labelled reagent. The demethylation of 7 using 48 HBr in 1butyl3methylimidazolium tetrafluoborate gave the corresponding 2Hlabelled 6Odesmethylated metabolite 8. Copyright © 2008 John Wiley & Sons, Ltd.
Details
- Language :
- English
- ISSN :
- 03624803 and 10991344
- Volume :
- 51
- Issue :
- 5
- Database :
- Supplemental Index
- Journal :
- Journal of Labelled Compounds and Radiopharmaceuticals
- Publication Type :
- Periodical
- Accession number :
- ejs14184924
- Full Text :
- https://doi.org/10.1002/jlcr.1511