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Chemo-enzymatic synthesis of pharmaceutical intermediates
- Source :
- Expert Opinion on Drug Discovery; February 2008, Vol. 3 Issue: 2 p187-245, 59p
- Publication Year :
- 2008
-
Abstract
- Chirality is a key factor in the safety and efficacy of many drug products and, thus, the production of single enantiomers of drug intermediates has become increasingly important in the pharmaceutical industry. There has been an increasing awareness of the enormous potential of microorganisms and enzymes derived therefrom for the transformation of synthetic chemicals with high chemo-, regio- and enantioselectivities. In this article, some selected enzymatic processes are described for the synthesis of chiral intermediates for pharmaceuticals.
Details
- Language :
- English
- ISSN :
- 17460441 and 1746045X
- Volume :
- 3
- Issue :
- 2
- Database :
- Supplemental Index
- Journal :
- Expert Opinion on Drug Discovery
- Publication Type :
- Periodical
- Accession number :
- ejs13583883
- Full Text :
- https://doi.org/10.1517/17460441.3.2.187