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Action of cholecystokinin on the dog sphincter of Oddi: Influence of anticholinergic agents
- Source :
- Archives of Physiology and Biochemistry; 1990, Vol. 98 Issue: 2 p353-360, 8p
- Publication Year :
- 1990
-
Abstract
- Effects of cholecystokinin (CCK) on bile flow through the sphincter of Oddi (SO) were studied in anaesthetized dogs. Intravenous injection of CCK (0.25, 0.5, 1 and 2 IDU/Kg) elicited a dose-dependent reduction in flow through the SO in the first minutes after CCK administration. Pirenzepine and atropine decreased significantly (P < 0.05) by 29% and a 40% respectively the inhibitory effect induced by 1 IDU/Kg of CCK, whereas hexamethonium elicited an increase in the inhibitory effect induced by 0.5 IDU/Kg of CCK (P < 0.05). Intravenous infusion of cummulative doses of CCK had different effects according to the dose infused. Lower doses (0.025 and 0.05 IDU/Kg/min) increased transphincteric flow, however, high doses (0.1, 0.2 and 0.4 IDU/Kg/min) were inhibitory. These finding indicated that CCK had two effects on the SO: firstly, a contractile effect, probably mediated through a direct myogenic action and neuronal release of ACh, and secondly a relaxant effect, probably mediated by stimulation of inhibitory postganglionic neurons.
Details
- Language :
- English
- ISSN :
- 13813455 and 17444160
- Volume :
- 98
- Issue :
- 2
- Database :
- Supplemental Index
- Journal :
- Archives of Physiology and Biochemistry
- Publication Type :
- Periodical
- Accession number :
- ejs13336908
- Full Text :
- https://doi.org/10.3109/13813459009113997