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Solid and Papillary Neoplasm of the Pancreas

Authors :
Jøsrgensen, Lars
Hansen, Alastair
Burcharth, Flemming
Philipsen, Else
Horn, Thomas
Source :
Ultrastructural Pathology; 1992, Vol. 16 Issue: 6 p659-666, 8p
Publication Year :
1992

Abstract

In two cases of solid and papillary neoplasm of the pancreas (SPN), positive staining for argyrophil granules, chromogranin-A, neuron-specific enolase, chymotrypsin, α1-antitrypsin, vimentin, cytokeratin, and estrogen receptors was present. Ultrastructurally, neurosecretory as well as zymogenlike granules were demonstrated. Measurements of mean nuclear volume and volume-corrected mitotic index discriminated between SPN and well-differentiated ductal adenocarcinoma of the pancreas, with notably lower values being seen in SPN. Silver-stained nucleolar organizer region counts showed wide overlaps. The results suggest that SPN is a tumor with mixed endocrine and exocrine features. Its low malignant potential compared to ductal adenocarcinoma is reflected in the mean nuclear volume and volume-corrected mitotic index. The presence of estrogen receptors may prove therapeutically useful.

Details

Language :
English
ISSN :
01913123 and 15210758
Volume :
16
Issue :
6
Database :
Supplemental Index
Journal :
Ultrastructural Pathology
Publication Type :
Periodical
Accession number :
ejs13120752
Full Text :
https://doi.org/10.3109/01913129209023755