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Association of a variant of the angiotensinogen gene with pure type of hypertension in pregnancy in the Japanese: Implication of a racial difference and significance of an age factor
- Source :
- American Journal of Medical Genetics. Part A; 17 September 1999, Vol. 86 Issue: 3 p232-236, 5p
- Publication Year :
- 1999
-
Abstract
- The contribution of genetic factors to hypertension in pregnancy, including pre-eclampsia, has been well documented. The association with a common molecular variant of the angiotensinogen (AGT) gene, in which methionine (M235) is substituted for threonine (T235) at residue 235, has been reported in both Caucasians and Japanese. In the present study, we examined 115 cases of pure type of hypertension in pregnancy (PHP) and 381 normal pregnant controls in order to look for subgroups in which the AGT gene is the major factor in the PHP pathogenesis. By classification of PHP cases according to the clinical diagnosis, gravidity, and maternal age, we found significantly higher frequencies of T235 in both all PHP patients and preeclampsia/eclampsia patients than in normal controls. These results are discordant with those reported for Caucasian subjects where only a group of preeclamptic primigravidae was associated with the AGT variant, possibly indicating the existence of a racial difference. We also found that the variant frequency was significantly higher in the PHP subgroup with maternal age of 2034 years (0.93) than in a subgroup of multigravid PHP patients age 35 years or older (0.77, P < 0.05) or in normal controls of age 2034 years (0.76, P < 0.001). The result indicates that the AGT variant plays a significant role in hypertension in the age group 2034 years. Am. J. Med. Genet. 86:232236, 1999. © 1999 Wiley-Liss, Inc.
Details
- Language :
- English
- ISSN :
- 15524825 and 15524833
- Volume :
- 86
- Issue :
- 3
- Database :
- Supplemental Index
- Journal :
- American Journal of Medical Genetics. Part A
- Publication Type :
- Periodical
- Accession number :
- ejs1285398
- Full Text :
- https://doi.org/10.1002/(SICI)1096-8628(19990917)86:3<232::AID-AJMG7>3.0.CO;2-2