Prothrombin and the prothrombin 20210 G to A polymorphism: their relationship with hypercoagulability and thrombosis

Polymorphisms of several clotting factors have been associated during the past few years with an increased risk of both venous or arterial thrombosis. However, final proof for the existence of a pathogenetic relationship between a given polymorphism and an increased risk for thrombosis is still lacking.