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Photoinduced DNA Cleavage by Cyclopentadienyl Metal Complexes Conjugated to DNA Recognition Elements
- Source :
- Organic Letters; August 2001, Vol. 3 Issue: 17 p2761-2764, 4p
- Publication Year :
- 2001
-
Abstract
- <UFIGR ID="ol0163676n00001">DNA recognition elements have been attached to CpW(CO)<INF>3</INF>CH<INF>3</INF> and CpW(CO)<INF>3</INF>Ph, which produce methyl and phenyl radicals that cleave DNA upon photolysis. The inclusion of binding moieties in <BO>3</BO> increases the efficiency but not the selectivity of strand scission over that seen in the simple unfunctionalized complex, while <BO>11</BO> cleaves preferentially at T sites within AT-rich tracts.
Details
- Language :
- English
- ISSN :
- 15237060 and 15237052
- Volume :
- 3
- Issue :
- 17
- Database :
- Supplemental Index
- Journal :
- Organic Letters
- Publication Type :
- Periodical
- Accession number :
- ejs1161477