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Anti-Hiv-1 Activity of 2',3'-Dideoxinucleoside Analogues : Structure-Activity Relationship

Anti-Hiv-1 Activity of 2',3'-Dideoxinucleoside Analogues : Structure-Activity Relationship

Authors :
De Clercq, Erik
Van Aerschot, Arthur
Herdewijn, Piet
Baba, Masanori
Pauwels, Rudi
Balzarini, Jan
Source :
Nucleosides and Nucleotides; January 1989, Vol. 8 Issue: 5 p659-671, 13p
Publication Year :
1989

Abstract

Among the purine and pyrimidine 2',3'-dideoxynucleosides, 2',3'-didehydro-2',3'-dideoxynucleosides, 3'-azido-2',3'-dideoxynucleosides and 3'-fluoro-2',3'-dideoxynucleosides, several congeners have been identified which achieve a potent and selective inhibition of HIV-1 replication in vitro.

Details

Language :
English
ISSN :
07328311
Volume :
8
Issue :
5
Database :
Supplemental Index
Journal :
Nucleosides and Nucleotides
Publication Type :
Periodical
Accession number :
ejs11608014
Full Text :
https://doi.org/10.1080/07328318908054206