Synthesis and Antiviral Activities of Some New 5-Heteroaromatic Substituted Derivatives of 2'-Deoxyuridine

Authors :: Liu, J.
Van Aerschot, A.
Luyten, I.
Wigerinck, P.
Pannecouque, C.
Balzarini, J.
De Clercq, E.
Herdewijn, P.
Source :: Nucleosides and Nucleotides; May 1995, Vol. 14 Issue: 3 p525-528, 4p
Publication Year :: 1995
Abstract: Eight new 5-heteroaromatic substituted analogues of 2'-deoxyuridine have been synthesized and evaluated for their inhibitory properties against a panel of different viruses. Several analogues containing a substituted thiophene moiety proved to be highly selective against herpes simplex virus type 1 (HSV-1).

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