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Design, Synthesis, and Evaluation of a Novel Class of Enantioselective Electrophilic Fluorinating Agents:  N-Fluoro Ammonium Salts of cinchona Alkaloids (F-CA-BF<INF>4</INF>)
- Source :
- Organic Letters; November 2000, Vol. 2 Issue: 23 p3699-3701, 3p
- Publication Year :
- 2000
-
Abstract
- <UFIGR ID="ol006610ln00001">The first enantiopure N-fluoro quaternary ammonium salts of cinchona alkaloids as enantioselective fluorinating agents are reported. A one-step transfer−fluorination on the naturally occurring cinchona alkaloids gave the fluorinating agents F-CA-BF<INF>4</INF>. This new generation of fluorinating agents exhibited asymmetric induction up to 61% on fluorination of enolates and silyl enol ethers of 2-methyl-1-tetralone.
Details
- Language :
- English
- ISSN :
- 15237060 and 15237052
- Volume :
- 2
- Issue :
- 23
- Database :
- Supplemental Index
- Journal :
- Organic Letters
- Publication Type :
- Periodical
- Accession number :
- ejs1160646