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Diastereoselective Formation of Methylene-Bridged Glycoluril Dimers
- Source :
- Organic Letters; March 2000, Vol. 2 Issue: 6 p755-758, 4p
- Publication Year :
- 2000
-
Abstract
- <UFIGR ID="ol991382kn00001">The acid-catalyzed formation of methylene-bridged glycoluril dimers yields the C<INF>2</INF><INF>v</INF><INF></INF>-diastereomer selectively. Product resubmission experiments establish that the selectivity is the result of thermodynamic control. A modified synthetic route is presented that allows for the preparation of unsymmetrically substituted dimers. We present the X-ray crystal structures of both diastereomers. This class of compounds is useful for studies of self-assembly in aqueous solution.
Details
- Language :
- English
- ISSN :
- 15237060 and 15237052
- Volume :
- 2
- Issue :
- 6
- Database :
- Supplemental Index
- Journal :
- Organic Letters
- Publication Type :
- Periodical
- Accession number :
- ejs1159952