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An Expedient Method for Resolution of 3-Amino-3-(3-pyridyl)propionic Acid and Related Compounds
- Source :
- Organic Process Research & Development; January 2001, Vol. 5 Issue: 1 p23-27, 5p
- Publication Year :
- 2001
-
Abstract
- Preparation of methyl (S)-3-amino-3-(3-pyridyl)propionate dihydrochloride in high enantiomeric purity by selective crystallization of a diastereomeric salt of a carboxylic acid precursor (N-BOC-protected) with (1R,2S)-(−)-ephedrine is described. Further demonstration of the usefulness of this procedure to resolve other 3-amino-3-[(substituted)pyridyl]propionic acids is also described.
Details
- Language :
- English
- ISSN :
- 10836160 and 1520586X
- Volume :
- 5
- Issue :
- 1
- Database :
- Supplemental Index
- Journal :
- Organic Process Research & Development
- Publication Type :
- Periodical
- Accession number :
- ejs1156347