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Synthesis of 2-Chloro-6-aryloxy- and 2-Chloro-6-alkoxyarylpurines and Their Properties in the Purine Nucleoside Phosphorylase (PNP) System
- Source :
- Nucleosides and Nucleotides; April 1999, Vol. 18 Issue: 4-5 p873-874, 2p
- Publication Year :
- 1999
-
Abstract
- AbstractA series of 2-chloro-6-aryloxy- and 2-chloro-6-alkoxyarylpurines was synthesized and their kinetic properties in the purine nucleoside phosphorylase (PNP) system were determined. All compounds showed inhibitory activity (IC50in the range 0.5-76 μM) vs.hexameric (“high-molecular weight”) PNP from E. coli.By contrast, no inhibition vs.trimeric CellulomonasPNP was detected.
Details
- Language :
- English
- ISSN :
- 07328311
- Volume :
- 18
- Issue :
- 4-5
- Database :
- Supplemental Index
- Journal :
- Nucleosides and Nucleotides
- Publication Type :
- Periodical
- Accession number :
- ejs11424285
- Full Text :
- https://doi.org/10.1080/15257779908041587