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Telomere shortening in human HL60 cells by treatment with deoxyguanosine analogs
- Source :
- Nucleic Acids Symposium Series; November 2004, Vol. 48 Issue: 1 p187-187, 1p
- Publication Year :
- 2004
-
Abstract
- Telomerase is a cellular endogenous reverse transcriptase thought to play an important role in the maintenance of telomere length. We investigated the effects of 3′-azido-2′,3′-dideoxyguanosine (AZddG) and carbocyclic oxetanocin G (C.OXT-G), of which the triphosphate derivatives AZddGTP and C.OXT-GTP show potent telomerase inhibition, on telomere length of human HL60 cells in culture. Although AZddG caused more significant telomere shortening than C.OXT-G, only a slight decrease of cell growth rate was observed.
Details
- Language :
- English
- ISSN :
- 02613166 and 17468272
- Volume :
- 48
- Issue :
- 1
- Database :
- Supplemental Index
- Journal :
- Nucleic Acids Symposium Series
- Publication Type :
- Periodical
- Accession number :
- ejs10499915
- Full Text :
- https://doi.org/10.1093/nass/48.1.187