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Clinical usefulness of 3% hydrogen peroxide in acute upper GI bleeding: a pilot study

Authors :
Kalloo, A.N.
Canto, M.I.
Wadwa, K.S.
Smith, C.L.
Gislason, G.T.
Okolo, P.I.
Pasricha, P.J.
Source :
Gastrointestinal Endoscopy; April 1999, Vol. 49 Issue: 4 p518-521, 4p
Publication Year :
1999

Abstract

Background: A major problem in the endoscopic management of acute upper gastrointestinal (GI) bleeding is the presence of blood and clots overlying the bleeding source, preventing visualization of the lesion. A simple alternative is to alter the characteristics of blood such that it not only becomes easier to remove but also becomes translucent. We report the results of a pilot study on the use of hydrogen peroxide in patients with acute upper GI bleeding. Methods: Patients with acute upper GI bleeding were studied if the presence of blood or clots obscured the site of bleeding. The potential site of bleeding was initially sprayed with 200 mL water and then with 200 mL 3% hydrogen peroxide mixed with simethicone. Results: In 6 patients with acute upper GI bleeding, hydrogen peroxide spray resulted in good to excellent visualization of the bleeding source. Hemostasis occurred in 2 patients who were actively bleeding. There were no adverse effects or complications. Conclusions: Hydrogen peroxide significantly enhanced clot dissolution and endoscopic visualization in patients with acute upper GI bleeding.

Details

Language :
English
ISSN :
00165107
Volume :
49
Issue :
4
Database :
Supplemental Index
Journal :
Gastrointestinal Endoscopy
Publication Type :
Periodical
Accession number :
ejs10260511
Full Text :
https://doi.org/10.1016/S0016-5107(99)70055-6