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New Zinc(II)-Based Catalyst for Asymmetric Azomethine Ylide Cycloaddition Reactions
- Source :
- Organic Letters; October 2006, Vol. 8 Issue: 21 p4687-4690, 4p
- Publication Year :
- 2006
-
Abstract
- A new chiral aziridino alcohol ligand for zinc(II)-catalyzed azomethine ylide cycloadditions is described. In the presence of this catalyst, N-arylidene glycine methyl esters react with a variety of dipolarophiles to give substituted pyrrolidines in very good to excellent chemical yields and up to 95% ee. The absolute sense of asymmetric induction appears to be dipolarophile-dependent.
Details
- Language :
- English
- ISSN :
- 15237060 and 15237052
- Volume :
- 8
- Issue :
- 21
- Database :
- Supplemental Index
- Journal :
- Organic Letters
- Publication Type :
- Periodical
- Accession number :
- ejs10180163
- Full Text :
- https://doi.org/10.1021/ol061521f