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Multiple Lung Adenocarcinomas Associated With Von Hippel-Lindau Disease.
- Source :
- Annals of Thoracic Surgery; Oct2014, Vol. 98 Issue 4, p1467-1470, 4p
- Publication Year :
- 2014
-
Abstract
- Lung adenocarcinoma has never before been reported to be associated with von Hippel-Lindau (VHL) disease. Here, we report a case of VHL disease in a patient who had metachronous multiple lung adenocarcinomas. The patient is a 64-year-old-woman with VHL disease. She underwent surgical resection of one adenocarcinoma and one atypical adenomatous hyperplasia. A second lung adenocarcinoma developed metachronously. A point mutation in the VHL gene was confirmed in DNA from a blood sample, and loss of heterozygosity at the VHL locus was detected in the lung adenocarcinoma. The VHL dysfunction may have a role in the development of multiple lung adenocarcinomas. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00034975
- Volume :
- 98
- Issue :
- 4
- Database :
- Supplemental Index
- Journal :
- Annals of Thoracic Surgery
- Publication Type :
- Academic Journal
- Accession number :
- 98355609
- Full Text :
- https://doi.org/10.1016/j.athoracsur.2013.11.080