Back to Search
Start Over
Vibration Response Imaging in Idiopathic Pulmonary Fibrosis: A Pilot Study.
- Source :
- Respiratory Care; Jul2014, Vol. 59 Issue 7, p1071-1077, 7p
- Publication Year :
- 2014
-
Abstract
- BACKGROUND: Vibration response imaging (VRI) is a novel imaging technique and little is known about its characteristics and diagnostic value in idiopathic pulmonary fibrosis (IPF). The aim of this study was to investigate the features of VRI in subjects with IPF. METHODS: We enrolled 23 subjects with IPF (42-74 y old) and 28 healthy subjects (42-72 y old). Subjects with IPF were diagnosed by lung biopsy and underwent VRI, spirometry, lung diffusion testing, and chest x-ray or computed tomography, which entailed assessment of the value of VRI indices. RESULTS: The total VRI score correlated statistically with single-breath carbon monoxide diffusing capacity percent predicted (r = -0.30, P = .04), but not with FVC percent predicted, FEV<subscript>1</subscript> percent predicted, and FEV<subscript>1</subscript>/FVC (r = -0.27, -0.22, and 0.19; all P > .05). Compared with healthy subjects (17.9%), 20 subjects with IPF (86.96%, P < .01) presented with significantly increased crackles. The difference in quality lung data in all lung regions was unremarkable (all P > .05), except for the upper right and lower left lobes (P < .05). Overall, VRI parameters yielded acceptable assay sensitivity and specificity. Maximum energy frame was characterized by the highest diagnostic value (sensitivity, 1.00; specificity, 0.82), followed by presence of abundant crackles (sensitivity, 0.70; specificity, 0.96). Total VRI score was not a sensitive indicator of IPF, owing to low assay sensitivity (0.70) and specificity (0.64). CONCLUSIONS: VRI may be helpful to discriminate between IPF subjects and healthy individuals. Maximum energy frame and abundant crackles might serve as a diagnostic tool for IPF. [ABSTRACT FROM AUTHOR]
- Subjects :
- IDIOPATHIC pulmonary fibrosis
ACADEMIC medical centers
CHI-squared test
DIAGNOSTIC imaging
HEALTH outcome assessment
RESEARCH funding
STATISTICS
T-test (Statistics)
VIBRATION (Mechanics)
PILOT projects
DATA analysis
TREATMENT effectiveness
DATA analysis software
DESCRIPTIVE statistics
DIAGNOSIS
Subjects
Details
- Language :
- English
- ISSN :
- 00201324
- Volume :
- 59
- Issue :
- 7
- Database :
- Supplemental Index
- Journal :
- Respiratory Care
- Publication Type :
- Academic Journal
- Accession number :
- 96867750
- Full Text :
- https://doi.org/10.4187/respcare.02739