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Divalent cation tolerance protein binds to β-secretase and inhibits the processing of amyloid precursor protein.
- Source :
- Neural Regeneration Research; 4/15/2013, Vol. 8 Issue 11, p991-999, 9p
- Publication Year :
- 2013
-
Abstract
- The article discusses a study of the interaction of divalent cation tolerance protein (DCTP) and the intracellular domain of beta-site amyloid precursor protein-cleaving enzyme (APPCE) 1 and their roles in the development of Alzheimer's disease. The researchers found an association between DCTP and endogenous beta-site APPCE 1 in the neuroblastoma cell line N2a using the yeast two-hybrid system. They also observed that DCTP reduces the processing of APP.
Details
- Language :
- English
- ISSN :
- 16735374
- Volume :
- 8
- Issue :
- 11
- Database :
- Supplemental Index
- Journal :
- Neural Regeneration Research
- Publication Type :
- Academic Journal
- Accession number :
- 94923886
- Full Text :
- https://doi.org/10.3969/j.issn.1673-5374.2013.11.004