Back to Search
Start Over
Replication of clinical associations with 17-hydroxyprogesterone in preterm newborns.
- Source :
- Journal of Pediatric Endocrinology & Metabolism; Apr2012, Vol. 25 Issue 3/4, p301-305, 5p
- Publication Year :
- 2012
-
Abstract
- Nationally, newborn screening programs use 17-hydroxyprogesterone (17-OHP) as the biomarker to detect the rare but potentially fatal inherited disease, congenital adrenal hyperplasia. However, this biomarker is highly variable, with a high false-positive rate of detection, particularly in neonates born preterm. Several studies have examined various clinical and genetic factors to explain the variability of 17-OHP in preterm infants. The purpose of this study was to replicate previous clinical and genetic associations with 17-OHP in a well-characterized cohort of 762 preterm infants. We replicated previous findings that respiratory distress syndrome (p=2×10<superscript>-3</superscript>) is associated with higher 17-OHP. Higher 17-OHP and false positives were significantly associated with lower gestational age and birth weight, as previously reported. Incorporating gestational age and birth weight together decreases the false-positive rate. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 0334018X
- Volume :
- 25
- Issue :
- 3/4
- Database :
- Supplemental Index
- Journal :
- Journal of Pediatric Endocrinology & Metabolism
- Publication Type :
- Academic Journal
- Accession number :
- 94659906
- Full Text :
- https://doi.org/10.1515/jpem-2011-0456