Anti-HSV-1 and antioxidant activities of dicaffeoyl and digalloyl esters of quinic acid.

Abstract: Nine caffeic and gallic acids derivatives were synthesized and evaluated for their antioxidant activity using the DPPH radical scavenging activity assay and for their antiherpes activity against HSV-1. All compounds displayed higher antioxidant activities than α-tocopherol. The most active antioxidant was compound 8 (IC₅₀ =177μM). Five compounds (7, 10, 11, 12 and 14) were found to possess anti-HSV-1 activity with selectivity indices values ranging from 7.0 to 27.1. The most active was compound 10 (IC₅₀ =15.2μM; SI=27.1). [Copyright &y& Elsevier]