A probable case of acromegaly from the Windmiller culture of prehistoric Central California.

Highlights: [•] An adult human skeleton from Central California shows craniofacial and postcranial osseous changes consistent with a diagnosis of acromegaly. [•] Acromegaly is a rare disorder that has not been well-documented in prehistoric remains, especially from North America. [•] This case study attempts to apply recent clinical criteria for diagnosing endocrine disorders in human skeletal remains. [Copyright &y& Elsevier]