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Indolent peripheral T-cell lymphoma involving the gastrointestinal tract.
- Source :
- Human Pathology; 2014, Vol. 45 Issue 2, p421-426, 6p
- Publication Year :
- 2014
-
Abstract
- We describe an unusual case of indolent peripheral T-cell lymphoma with multifocal involvement of the gastrointestinal tract. The patient, a 42-year-old Asian man, has been followed up for more than 10 years without chemotherapy and multiple gastrointestinal biopsies showing similar findings. Histologically, the neoplasm expanded into the lamina propria and/or focally extended into the submucosa and was composed of small- to medium-sized lymphocytes with slightly irregular nuclear contours and clear cytoplasm and rare large lymphocytes. The tumor cells were positive for CD3, CD8, granzyme B, and TIA-1 (subset) and negative for CD5, CD56, and Epstein-Barr virus-encoded RNA. Molecular studies for T-cell receptor γand/or β chain gene rearrangement demonstrated the same clone at different sites and times during the course of the disease. Rare cases of indolent peripheral T-cell lymphoma of the gastrointestinal tract have been previously described and need to be further characterized to avoid the use of aggressive chemotherapy. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00468177
- Volume :
- 45
- Issue :
- 2
- Database :
- Supplemental Index
- Journal :
- Human Pathology
- Publication Type :
- Academic Journal
- Accession number :
- 93738559
- Full Text :
- https://doi.org/10.1016/j.humpath.2013.08.003