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The relation of circulating YKL-40 to levels and decline of lung function in adult life.
- Source :
- Respiratory Medicine; 2013, Vol. 107 Issue 12, p1923-1930, 8p
- Publication Year :
- 2013
-
Abstract
- Background: YKL-40 is a chitinase-like protein that, in cross-sectional clinical studies, has been associated with severe asthma and COPD in smokers. Aim: To determine the longitudinal relation of circulating YKL-40 to levels and decline of lung function in the general population. Methods: We used longitudinal data from up to 13 surveys from the population-based TESAOD study which was conducted in Tucson, Arizona between 1972 and 1996. In cross-sectional analyses, we also used data from 3 Spanish centers of the multicenter ECRHS study (ECRHS-Sp). Serum YKL-40 was measured at baseline in TESAOD and in survey 2 in ECRHS-Sp using ELISAs. Multivariate linear regression was used to test associations of serum YKL-40 to concomitant lung function. In TESAOD, random coefficients models were used to test associations of serum YKL-40 to subsequent decline of lung function. Results: Data on YKL-40 and lung function were available from 1088 TESAOD and 854 ECRHS-Sp adult participants (59% and 51% females; respectively). In adjusted multivariate meta-analyses, being in the highest YKL-40 quartile was associated cross-sectionally with significant deficits in FEV1 and FVC %predicted. In adjusted longitudinal analyses, TESAOD participants in the top YKL-40 quartile had an FEV1 decline that was 5 ml/yr (p = 0.05) faster than subjects in the third quartile, 5 ml/yr (p = 0.02) faster than subjects in the second quartile, and 10 ml/yr (p < 0.001) faster than subjects in the lowest YKL-40 quartile. These longitudinal effects were particularly strong in smokers and absent in never smokers. After adjusting for covariates, as compared with the other three quartiles combined, the top YKL-40 quartile was associated with a 9 ml/yr (p = 0.001) faster FEV<subscript>1</subscript> decline among smokers, while no significant effects were found among never smokers (2 ml/yr, p = 0.35). Conclusions: Circulating YKL-40 is associated with levels and decline of lung function in the general population and may be a biomarker of susceptibility to the long-term effects of cigarette smoking. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09546111
- Volume :
- 107
- Issue :
- 12
- Database :
- Supplemental Index
- Journal :
- Respiratory Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 92884564
- Full Text :
- https://doi.org/10.1016/j.rmed.2013.07.013