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Chitosan-g-hematin: Enzyme-mimicking polymeric catalyst for adhesive hydrogels.
- Source :
- Acta Biomaterialia; Jan2014, Vol. 10 Issue 1, p224-233, 10p
- Publication Year :
- 2014
-
Abstract
- Abstract: Phenol derivative-containing adhesive hydrogels has been widely recognized as having potential for biomedical applications, but their conventional production methods, utilizing a moderate/strong base, alkaline buffers, the addition of oxidizing agents or the use of enzymes, require alternative approaches to improve their biocompatibility. In this study, we report a polymeric, enzyme-mimetic biocatalyst, hematin-grafted chitosan (chitosan-g-hem), which results in effective gelation without the use of alkaline buffers or enzymes. Furthermore, gelation occurs under mild physiological conditions. Chitosan-g-hem biocatalyst (0.01%, w/v) has excellent catalytic properties, forming chitosan–catechol hydrogels rapidly (within 5min). In vivo adhesive force measurement demonstrated that the hydrogel formed by the chitosan-g-hem activity showed an increase in adhesion force (33.6±5.9kPa) compared with the same hydrogel formed by pH-induced catechol oxidation (20.6±5.5kPa) in mouse subcutaneous tissue. Using the chitosan-g-hem biocatalyst, other catechol-functionalized polymers (hyaluronic acid–catechol and poly(vinyl alcohol)–catechol) also formed hydrogels, indicating that chitosan-g-hem can be used as a general polymeric catalyst for preparing catechol-containing hydrogels. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 17427061
- Volume :
- 10
- Issue :
- 1
- Database :
- Supplemental Index
- Journal :
- Acta Biomaterialia
- Publication Type :
- Academic Journal
- Accession number :
- 92502511
- Full Text :
- https://doi.org/10.1016/j.actbio.2013.09.014