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Mammaglobin and S-100 immunoreactivity in salivary gland carcinomas other than mammary analogue secretory carcinoma.

Authors :
Patel, Kalyani R.
Solomon, Isaac H.
El-Mofty, Samir K.
Lewis Jr., James S.
Chernock, Rebecca D.
Source :
Human Pathology; 2013, Vol. 44 Issue 11, p2501-2508, 8p
Publication Year :
2013

Abstract

Mammary analogue secretory carcinoma (MASC) is a recently described salivary gland tumor that has morphologic features similar to secretory carcinoma of the breast and that also harbors the same ETV6 translocation. Diffuse mammaglobin and S-100 immunoreactivity are used to differentiate MASC from its morphologic mimics, especially acinic cell carcinoma and adenocarcinoma, not otherwise specified. However, the combination of mammaglobin and S-100 immunoreactivity has not been well studied in other types of salivary gland carcinomas that may have focal areas reminiscent of MASC. Here we evaluated mammaglobin and S-100 immunoreactivity in 15 cases each of polymorphous lowgrade adenocarcinoma, adenoid cystic carcinoma and mucoepidermoid carcinoma, and also in 2 cases of adenocarcinoma, not otherwise specified, and 1 mucinous adenocarcinoma. Cases with significant coexpression of mammaglobin and S-100 (moderate or strong immunoreactivity in N25% of tumor cells) were further analyzed by fluorescence in situ hybridization using the ETV6 (12p13) break-apart probe. Nine cases (60%) of polymorphous low-grade adenocarcinoma and two (13.3%) of adenoid cystic carcinoma met the criteria for significant co-expression of mammaglobin and S-100. All were negative for the ETV6 translocation by fluorescence in situ hybridization. Although mammaglobin and S-100 positivity was seen in the majority of polymorphous low-grade adenocarcinomas and a minority of adenoid cystic carcinomas, none were positive for the ETV6 translocation characteristic of MASC. This indicates a need for caution in the use of immunohistochemistry for diagnosing MASC, especially in the absence of cytogenetic confirmation. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00468177
Volume :
44
Issue :
11
Database :
Supplemental Index
Journal :
Human Pathology
Publication Type :
Academic Journal
Accession number :
91539831
Full Text :
https://doi.org/10.1016/j.humpath.2013.06.010