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Classical and Alternative End-Joining Pathways for Repair of Lymphocyte-Specific and General DNA Double-Strand Breaks.
- Source :
- Advances in Immunology; Oct2012, Vol. 116, p1-49, 49p
- Publication Year :
- 2012
-
Abstract
- Abstract: Classical nonhomologous end joining (C-NHEJ) is one of the two major known pathways for the repair of DNA double-strand breaks (DSBs) in mammalian cells. Our understanding of C-NHEJ has been derived, in significant part, through studies of programmed physiologic DNA DSBs formed during V(D)J recombination in the developing immune system. Studies of immunoglobulin heavy-chain (IgH) class-switch recombination (CSR) also have revealed that there is an “alternative” end-joining process (A-EJ) that can function, relatively robustly, in the repair of DSBs in activated mature B lymphocytes. This A-EJ process has also been implicated in the formation of oncogenic translocations found in lymphoid tumors. In this review, we discuss our current understanding of C-NHEJ and A-EJ in the context of V(D)J recombination, CSR, and the formation of chromosomal translocations. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 00652776
- Volume :
- 116
- Database :
- Supplemental Index
- Journal :
- Advances in Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 90533222
- Full Text :
- https://doi.org/10.1016/B978-0-12-394300-2.00001-6