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Antiretroviral-Treated HIV-Infected Women Have Similar Long-Term Kidney Function Trajectories as HIV-Uninfected Women.
- Source :
- AIDS Research & Human Retroviruses; May2013, Vol. 29 Issue 5, p755-760, 6p
- Publication Year :
- 2013
-
Abstract
- Natural history studies suggest increased risk for kidney function decline with HIV infection, but few studies have made comparisons with HIV-uninfected women. We examined whether HIV infection treated with highly active antiretroviral therapy (HAART) remains associated with faster kidney function decline in the Women's Interagency HIV Study. HIV-infected women initiating HAART with ( n=105) or without ( n=373) tenofovir (TDF) were matched to HIV-uninfected women on calendar and length of follow-up, age, systolic blood pressure, hepatitis C antibody serostatus, and diabetes history. Linear mixed models were used to evaluate differences in annual estimated glomerular filtration rate (eGFR). Person-visits were 4,741 and 11,512 for the TDF-treated and non-TDF-treated analyses, respectively. Mean baseline eGFRs were higher among women initiated on TDF-containing HAART and lower among those on TDF-sparing HAART compared to their respective HIV-uninfected matches ( p<0.05 for both). HIV-infected women had annual rates of eGFR changes similar to HIV-uninfected matches ( p-interaction >0.05 for both). Adjusting for baseline eGFR, mean eGFRs at 1 and 3 years of follow-up among women initiated on TDF-containing HAART were lower than their uninfected matches (−4.98 and −4.26 ml/min/1.73 m<superscript>2</superscript>, respectively; p<0.05 for both). Mean eGFR of women initiated on TDF-sparing HAART was lower versus uninfected matches at 5 years (-2.19 ml/min/1.73 m<superscript>2</superscript>, p=0.03). HAART-treated HIV-infected women had lower mean eGFRs at follow-up but experienced rates of annual eGFR decline similar to HIV-uninfected women. Tenofovir use in HIV-infected women with normal kidney function did not accelerate long-term kidney function decline relative to HIV-uninfected women. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 08892229
- Volume :
- 29
- Issue :
- 5
- Database :
- Supplemental Index
- Journal :
- AIDS Research & Human Retroviruses
- Publication Type :
- Academic Journal
- Accession number :
- 87338164
- Full Text :
- https://doi.org/10.1089/aid.2012.0248