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The evaluation and management of drug effects on cardiac conduction (PR and QRS Intervals) in clinical development.
- Source :
- American Heart Journal; Apr2013, Vol. 165 Issue 4, p489-500, 12p
- Publication Year :
- 2013
-
Abstract
- Recent advances in electrocardiographic monitoring and waveform analysis have significantly improved the ability to detect drug-induced changes in cardiac repolarization manifested as changes in the QT/corrected QT interval. These advances have also improved the ability to detect drug-induced changes in cardiac conduction. This White Paper summarizes current opinion, reached by consensus among experts at the Cardiac Safety Research Consortium, on the assessment of electrocardiogram-based safety measurements of the PR and QRS intervals, representing atrioventricular and ventricular conduction, respectively, during drug development. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 00028703
- Volume :
- 165
- Issue :
- 4
- Database :
- Supplemental Index
- Journal :
- American Heart Journal
- Publication Type :
- Academic Journal
- Accession number :
- 86462064
- Full Text :
- https://doi.org/10.1016/j.ahj.2013.01.011