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Paclitaxel loaded poly-d,l-lactide-co-glycolide nanoparticles: Enhanced anticancer effect in non-small cell lung carcinoma cell line.
- Source :
- Biomedicine & Preventive Nutrition; Jan2013, Vol. 3 Issue 1, p1-9, 9p
- Publication Year :
- 2013
-
Abstract
- Abstract: The aim of the present study was to develop PTX-PLGA nanoparticles and to study its anticancer efficacy in NCI-H460 cells in vitro. DLS results revealed that prepared PTX-PLGA had an average size of 211nm. TEM analysis showed that prepared PTX-PLGA nanoparticles were spherical in shape with 150nm. Drug encapsulation assay showed that 65% PTX was encapsulated in PLGA. It was noticed that anticancer potential of PTX-PLGA nanoparticles was greater than that of PTX treatment alone. Further, PLGA-PTX exhibits increased intracellular ROS levels, altered MMP, increased DNA damage, enhanced TBARS and apoptotic morphological changes in NCI-H460 cells when compared to bulk PTX treatment alone. Our results indicate that PTX-PLGA demonstrated increased anticancer property in cancer cells than PTX treatment alone. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 22105239
- Volume :
- 3
- Issue :
- 1
- Database :
- Supplemental Index
- Journal :
- Biomedicine & Preventive Nutrition
- Publication Type :
- Academic Journal
- Accession number :
- 85877520
- Full Text :
- https://doi.org/10.1016/j.bionut.2012.10.016