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A Dominant CD4+ T-Cell Response to Helicobacter pylori Reduces Risk for Gastric Disease in Humans.
- Source :
- Gastroenterology (00165085); Mar2013, Vol. 144 Issue 3, p591-600, 10p
- Publication Year :
- 2013
-
Abstract
- Background & Aims: Immunodominance is an important feature of antiviral, antitumor, and antibacterial cellular immune responses, but it is not well demonstrated in the immune responses against Helicobacter pylori. Antigen-specific CD4<superscript>+</superscript> T cells protect mice against infection with H pylori. We investigated the immunodominant CD4<superscript>+</superscript> T-cell response to neuraminyllactose-binding hemagglutinin (HpaA), which is a conserved, H pylori–specific colonization factor that is being investigated as an antigen for vaccination strategies. Methods: HpaA-specific CD4<superscript>+</superscript> T cells were expanded with autologous peripheral blood mononuclear cells that had been incubated with recombinant HpaA and characterized using overlapping synthetic peptides. We compared the percentage of CD4<superscript>+</superscript> T cells with specificity for HpaA<subscript>88–100</subscript>, restricted to HLA-DRB1*1501, among 59 H pylori–infected subjects with different gastric diseases. Results: We identified and characterized several immunodominant CD4<superscript>+</superscript> T-cell epitopes derived from HpaA. The immunodominant CD4<superscript>+</superscript> T-cell responses specific to HpaA<subscript>88–100</subscript> were observed in most H pylori–infected individuals who expressed HLA-DRB1*1501 and were significantly more abundant in patients with less severe diseases (P < .05). Conclusions: The HLA-DRB1*1501–restricted immunodominant CD4<superscript>+</superscript> T-cell response to HpaA<subscript>88–100</subscript> is associated with reduced risk of severe gastric diseases. Further study of these and other immunodominant CD4<superscript>+</superscript> T-cell responses to H pylori will provide insight into mechanisms of protective immunity and aid in vaccine design. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00165085
- Volume :
- 144
- Issue :
- 3
- Database :
- Supplemental Index
- Journal :
- Gastroenterology (00165085)
- Publication Type :
- Academic Journal
- Accession number :
- 85606607
- Full Text :
- https://doi.org/10.1053/j.gastro.2012.12.002