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A Dominant CD4+ T-Cell Response to Helicobacter pylori Reduces Risk for Gastric Disease in Humans.

Authors :
Chen, Li
Li, Bin
Yang, Wu–Chen
He, Jia–Lin
Li, Ning–Yi
Hu, Jian
He, Ya–Fei
Yu, Shu
Zhao, Zhuo
Luo, Ping
Zhang, Jin–Yong
Li, Hai–Bo
Zeng, Ming
Lu, Dong–Shui
Li, Bo–Sheng
Guo, Hong
Yang, Shi–Ming
Guo, Gang
Mao, Xu–Hu
Chen, Weisan
Source :
Gastroenterology (00165085); Mar2013, Vol. 144 Issue 3, p591-600, 10p
Publication Year :
2013

Abstract

Background & Aims: Immunodominance is an important feature of antiviral, antitumor, and antibacterial cellular immune responses, but it is not well demonstrated in the immune responses against Helicobacter pylori. Antigen-specific CD4<superscript>+</superscript> T cells protect mice against infection with H pylori. We investigated the immunodominant CD4<superscript>+</superscript> T-cell response to neuraminyllactose-binding hemagglutinin (HpaA), which is a conserved, H pylori–specific colonization factor that is being investigated as an antigen for vaccination strategies. Methods: HpaA-specific CD4<superscript>+</superscript> T cells were expanded with autologous peripheral blood mononuclear cells that had been incubated with recombinant HpaA and characterized using overlapping synthetic peptides. We compared the percentage of CD4<superscript>+</superscript> T cells with specificity for HpaA<subscript>88–100</subscript>, restricted to HLA-DRB1*1501, among 59 H pylori–infected subjects with different gastric diseases. Results: We identified and characterized several immunodominant CD4<superscript>+</superscript> T-cell epitopes derived from HpaA. The immunodominant CD4<superscript>+</superscript> T-cell responses specific to HpaA<subscript>88–100</subscript> were observed in most H pylori–infected individuals who expressed HLA-DRB1*1501 and were significantly more abundant in patients with less severe diseases (P < .05). Conclusions: The HLA-DRB1*1501–restricted immunodominant CD4<superscript>+</superscript> T-cell response to HpaA<subscript>88–100</subscript> is associated with reduced risk of severe gastric diseases. Further study of these and other immunodominant CD4<superscript>+</superscript> T-cell responses to H pylori will provide insight into mechanisms of protective immunity and aid in vaccine design. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00165085
Volume :
144
Issue :
3
Database :
Supplemental Index
Journal :
Gastroenterology (00165085)
Publication Type :
Academic Journal
Accession number :
85606607
Full Text :
https://doi.org/10.1053/j.gastro.2012.12.002