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Inflammatory Biomarkers as Risk Factors for Future Atrial Fibrillation. An Eleven-Year Follow-Up of 6315 Men and Women: The Tromsø Study.
- Source :
- Gender Medicine; Dec2012, Vol. 9 Issue 6, p536-547.e2, 0p
- Publication Year :
- 2012
-
Abstract
- Abstract: Background: Inflammatory biomarkers are reported as risk factors for atrial fibrillation (AF), but their impact is uncertain. Objective: We investigated the associations between inflammatory biomarkers and future AF in a large general cohort. Methods: Available markers were white blood cells (WBCs) with subgroups, fibrinogen, high-sensitivity C-reactive protein (hs-CRP), and osteoprotegerin (OPG). A total of 6315 men and women from a population survey in Tromsø, Norway in 1994 to 1995 were followed for a mean of 10.9 years. Mean age at baseline was 60 years. Measurements of height, weight, blood pressure, heart rate, total cholesterol, high-density lipoprotein (HDL) cholesterol, WBC count, and information on diabetes, angina, myocardial infarction, and antihypertensive treatment, were obtained at baseline. Fibrinogen, hs-CRP, and OPG were obtained at a follow-up visit. The outcome measure was first-ever AF, documented on an electrocardiogram. The Cox proportional hazards regression model was used to estimate hazard ratios of AF. Results: In the multivariable analysis, adjusted for traditional cardiovascular risk factors and other inflammatory biomarkers, hs-CRP was associated with AF in men only (hazard ratio = 1.14 for a 1 SD increase; 95% CI, 1.02–1.28). There was a significant increase in AF across quartiles of WBCs in men (P = 0.007) and in the total study population (P = 0.004). OPG was associated with AF in patients free of coronary heart disease at baseline. Fibrinogen and subgroups of WBCs showed no significant association with AF. Conclusion: This population-based cohort study showed that hs-CRP was independently associated with AF in men, but apparently not in women, and that patients with WBCs in the upper quartile had increased risk of AF. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 15508579
- Volume :
- 9
- Issue :
- 6
- Database :
- Supplemental Index
- Journal :
- Gender Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 84167957
- Full Text :
- https://doi.org/10.1016/j.genm.2012.09.001