Central Angiotensin-(1-7) Improves Vagal Function Independent of Blood Pressure in Hypertensive (mRen2)27 Rats.

The article explores whether blocking angiotensin II actions alters mean arterial pressure, baroreflex sensitivity or metabolic function. Mean arterial pressure was reduced in cadesartan-treated rats without significantly improving the vagal components of baroreflect function or heart rate variability. Findings demonstrate that blood pressure and baroreflex function can be essentially normalized independently of medullary nicotinamide adenine dinucleotide phosphate oxidase in hypertensive rats.