Effect of Skeletal Muscle Na+ Channel Delivered Via a Cell Platform on Cardiac Conduction and Arrhythmia Induction.

Authors :: Boink, Gerard J. J.
Jia Lu
Driessen, Helen E.
Lian Duan
Sosunov, Eugene A.
Anyukhovsky, Evgeny P.
Shlapakova, Iryna N.
Lau, David H.
Rosen, Tove S.
Danilo, Peter
Zhiheng Jia
Ozgen, Nazira
Bobkov, Yevgeniy
Guo, Yuanjian
Brink, Peter R.
Kryukova, Yelena
Robinson, Richard B.
Entcheva, Emilia
Cohen, Ira S.
Rosen, Michael R.
Source :: Circulation: Arrhythmia & Electrophysiology; Aug2012, Vol. 5 Issue 4, p831-840, 10p
Publication Year :: 2012
Abstract: The article discusses a study which examined the impact of canine mesenchymal stem cells (cMSC) in delivering skeletal muscle sodium (Na<superscript>+</superscript>) channel (SkM1). They involved the isolation and transfection of cMSCs with SkM1. The results revealed that cMSCs provide efficient delivery of SkM1 current and the interventions performed were neither antiarrhythmic nor proarrhythmic. The criticality of the delivery platform to SkM1 antiarrhythmic efficacy is also noted.

Subjects :: MESENCHYMAL stem cells
SKELETAL muscle
SODIUM
SODIUM channels
HEART conduction system
ARRHYTHMIA

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