Dopamine and Angiotensin Type 2 Receptors Cooperatively Inhibit Sodium Transport in Human Renal Proximal Tubule Cells.

The article focuses on the role played by dopamine D1-like receptors (D1R/D5R) and angiotensin type 2 receptor (AT2R) in decreasing sodium reabsorption in human renal proximal tubule cells. The authors were able to show in their study that D1R/D5R stimulation was able to reduce the ability of angiotensin II in stimulating phospo-extracellular signal-regulated kinase. They conclude that their study was able to show how dopaminergic and angiotensin systems can be used in treating hypertension.