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Biopsy of liver metastasis for women with breast cancer: Impact on survival.
- Source :
- Breast; Jun2012, Vol. 21 Issue 3, p284-288, 5p
- Publication Year :
- 2012
-
Abstract
- Abstract: Background: Biopsy of metastatic site of disease can influence treatment decisions, but its impact on survival remains uncertain. Patients and methods: One-hundred patients with first metachronous liver metastases (LM) from breast cancer (BC) who underwent liver biopsy between 1999 and 2009 were identified. One-hundred matched control patients with LM from BC and no biopsy were selected. Results: Liver biopsy had no statistically significant impact on survival when comparing biopsied patients to controls [HR 0.82 (95% CI 0.58–1.16)]. Patients with early metastasis (within 3 years) undergoing liver biopsy had a better survival [HR 0.60 (95% CI 0.38–0.97)] compared to those who did not. Liver biopsy had no statistically significant impact on survival in patients with late LM (after 3 years) [HR 1.09 (95% CI 0.69–1.74)]. We observed that 18 out of 100 biopsied patients (18.0%) had a conversion of predictive factors which allowed adjusting for therapy, specifically new expression of ER (n =5), overexpression of HER2 (n =12) or both (n =1). Fourteen out of 18 (77.8%) received anti-HER2 treatment for the first time at the time of metastasis and 3 others (16.7%) received hormone therapy. Those 18 patients showed a better survival compared to the other 82 biopsied patients [HR 0.55 (95% CI 0.28–1.10)] and compared to the 13 biopsied patients with disappearance of features which predicted responsiveness to a given treatment [HR 0.19 (95% CI 0.06–0.62)]. Conclusions: Liver biopsy can impact survival of patients with early metastases from BC. Discordance between primary and distant lesions can offer the patients new treatment options. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 09609776
- Volume :
- 21
- Issue :
- 3
- Database :
- Supplemental Index
- Journal :
- Breast
- Publication Type :
- Academic Journal
- Accession number :
- 76610424
- Full Text :
- https://doi.org/10.1016/j.breast.2011.12.014