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Mechanisms of Carbon Monoxide Attenuation of Tubuloglomerular Feedback.
- Source :
- Hypertension (0194911X); Jun2012, Vol. 59 Issue 6, p1139-1144, 6p
- Publication Year :
- 2012
-
Abstract
- The article presents a study that deals with the mechanisms underlying the role of carbon monoxide (CO) in attenuating tubuloglomerular feedback. The study investigated the influence of CO and cGMP-stimulated phosphodiesterase 2 in reducing cAMP in the macula densa, leading to TGF attenuation. It shows that TGF is attenuated by CO through reduction of cAMP via a cGMP-dependent pathway mediated by cGMP-dependent protein kinase.
Details
- Language :
- English
- ISSN :
- 0194911X
- Volume :
- 59
- Issue :
- 6
- Database :
- Supplemental Index
- Journal :
- Hypertension (0194911X)
- Publication Type :
- Academic Journal
- Accession number :
- 76560751
- Full Text :
- https://doi.org/10.1161/HYPERTENSIONAHA.112.192120