Asthma control assessed in the EGEA epidemiological survey and health-related quality of life.

Summary: Background: The aims were to assess 1) the relationship of asthma control assessed by combining epidemiological survey questions and lung function to Health-Related Quality of Life (HRQL) and 2) whether individuals with controlled asthma reach similar generic HRQL levels as individuals without asthma. Methods: The analysis included 584 individuals without asthma and 498 with asthma who participated in the follow-up of the Epidemiological study on Genetics and Environment of Asthma (EGEA). Asthma control was assessed from survey questions and lung function, closely adapted from the 2006–2009 Global Initiative for Asthma guidelines. The Asthma Quality of Life Questionnaire (AQLQ, scores range:1–7) and the generic SF-36 (scores range: 0–100) were used. Results: Adjusted mean total AQLQ score decreased by 0.5 points for each asthma control steps (6.4, 5.9 and 5.4 for controlled, partly-controlled and uncontrolled asthma respectively, p < 0.0001). The differences in SF-36 scores between individuals with controlled asthma and those without asthma were minor and not significant for the PCS (−1, p = 0.09), borderline significant for the MCS (−1.6, p = 0.05) and small for the 8 domains (<5.1) although statistically significant for 4 domains. Conclusion: These results support the discriminative properties of the proposed asthma control grading system and its use in epidemiology. [ABSTRACT FROM AUTHOR]