Apolipoprotein Isoform E4 Does Not Increase Coronary Heart Disease Risk in Carriers of Low-Density Lipoprotein Receptor Mutations.

The article investigates whether the low-density lipoprotein receptor (LDLR) locus interacted with the apolipoprotein E gene genotype on coronary heart disease risk in patients clinically diagnosed with familial hypercholesterolemia with and without LDLR mutation. The findings revealed that the apolipoprotein E4/E4 genotype was associated with lower coronary heart disease risk in patients with familial hypercholesterolemia with an LDLR mutation.