Negative effects of Notch1 on the differentiation of muscle-derived stem cells into neuronal-like cells.

The article discusses a study on the negative effects of Notch 1 on the differentiation of muscle-derived stem cells (MDSCs) into neuronal-like cells. The study discovered that MDSCs in the induced group cultured with differentiation medium multiplied well after being induced for 7 days, with cell bodies and processes strongly neuron-specific enolase (NSE) positive. The study also determined that Notch1 mRNA of induced group cells was largely decreased as compared to other group cells.