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Induced Th2 dominant immune response in APPswe, PSEN1dE9 transgenic mice after nasal immunization with an adenoviral vector encoding 10 tandem repeats of beta-amyloid 3-10.
- Source :
- Neural Regeneration Research; Sep2011, Vol. 6 Issue 26, p2005-2012, 8p
- Publication Year :
- 2011
-
Abstract
- The article focuses on the study regarding adenovirus vaccine construction containing CpG DNA gene adjuvant and 10 x Aβ<subscript>3-10</subscript>. It employed methods such as nasal immunization, anti-Aβ<subscript>42</subscript> IgG1 induction to transgenic Alzheimer's disease (AD) mice. Results show that 10 x Aβ<subscript>3-10</subscript> immunized mice showed improved memories than control mice.
Details
- Language :
- English
- ISSN :
- 16735374
- Volume :
- 6
- Issue :
- 26
- Database :
- Supplemental Index
- Journal :
- Neural Regeneration Research
- Publication Type :
- Academic Journal
- Accession number :
- 67472732
- Full Text :
- https://doi.org/10.3969/j.issn.1673-5374.2011.26.001