Upstream Use of Small-Molecule Glycoprotein IIb/IIIa Inhibitors in Patients With Non-ST-Segment Elevation Acute Coronary Syndromes.

The article focuses on the effect of upstream small-molecule glycoprotein (GP) IIb/IIIa inhibitors when used in non-ST-segment elevation acute coronary syndromes (NSTE ACS). The authors analyzed 12 randomized clinical trials that they assessed for tirofiban, eptifibatide and lamifiban. They found that an 11% reduction in 30-day death/myocardial infarction when upstream GP IIb/IIa inhibitor was used. The authors claim significant but modest ischemic benefit brought by the use of the inhibitor.