Stereochemical Differentiation in the Simmons-Smith Reaction for Cyclopropanated Glucopyranose Derivatives as Molecular Probes for Glycosidases.

The article discusses research which examines the stereochemical differentiation in the cyclopropanated glucopyranose derivatives' Simmons-Smith reaction as molecular probes for glycosidases. The study showed that the reaction mechanism for cellulases is indispensable in designing its artificial mutants in higher stability than those of natural cellulases. It revealed that glucopyranose derivatives were synthesized to mimic the unstable transition state conformation of enzymatic hydrolysis.