Serum insulin-like growth factor-I is negatively associated with serum adiponectin in type 2 diabetes mellitus.

Abstract: Background: Although insulin-like growth factor-I (IGF-I) and dehydroepiandrosterone-sulfate (DHEA-S) are involved in age-related diseases such as cardiovascular disease and diabetes mellitus, the association of these hormones with serum adiponectin level is still unclear. Objective and methods: To investigate the association between serum IGF-I and DHEA-S versus adiponectin, we conducted a cross-sectional study of 348 Japanese men with type 2 diabetes mellitus and examined their relationships. Serum total adiponectin level was measured by an ELISA kit. Results: Simple correlation analysis showed that patients'' age and duration of diabetes were negatively correlated with IGF-I and DHEA-S (p<0.01) and positively with adiponectin (p<0.01), while body mass index (BMI) was positively correlated with IGF-I and DHEA-S (p<0.001) and negatively with adiponectin (p<0.001). IGF-I was negatively correlated with adiponectin (r=−0.25, p<0.001) and DHEA-S was negatively correlated with adiponectin and HbA1c (r=−0.17, p=0.003 and r=−0.12, p=0.027, respectively). In multiple regression analysis adjusted for age, duration of diabetes, BMI, and serum creatinine, HbA1c was negatively associated with IGF-I and DHEA-S (β=−0.12, p=0.036 and β=−0.22, p<0.001, respectively). Adiponectin was negatively associated with IGF-I (β=−0.15, p=0.013), but not DHEA-S. Moreover, this association was still significant after additional adjustment for HbA1c (β=−0.18, p=0.005). Conclusions: Present cross-sectional study for the first time showed a negative association of serum IGF-I with serum adiponectin in Japanese men with type 2 diabetes independent of age, duration of diabetes, BMI, renal function, and HbA1c. [Copyright &y& Elsevier]